Open AccessMetabolic syndrome emerges after artificial selection for low baroreflex sensitivity
Author(s) -
Zhang LiLi,
Zhang Ying,
Cheng YanQiong,
Zhang JingMing,
Liu HongQi,
Wang WeiZhong,
Mehta Jawahar L.,
Xiong ZhiGang,
Su DingFeng,
Liu AiJun
Publication year - 2018
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12999
Subject(s) - metabolic syndrome , baroreflex , medicine , overweight , obesity , endocrinology , mechanism (biology) , cardiology , bioinformatics , blood pressure , biology , heart rate , philosophy , epistemology
Summary Aims It is unclear whether the impaired BRS plays a key role in the incidence of cardiovascular diseases. The molecular mechanism of impaired BRS remains to be fully elucidated. We hypothesized that selection of rats based on deficient and normal intrinsic BRS would yield models that reflect cardiovascular diseases risk. Methods and Results Twenty generations of selection produced arterial baroreflex low rats and normal rats that differed in BRS by about 2.5‐fold change. Metabolic syndrome (including hypertension, overweight, hyperlipemia, and hyperglycemia) emerged in ABR ‐ DR s. Although ABR ‐ DR s consumed less food, they gained significantly more body weight. Conclusion Our study demonstrated that intrinsic low BRS induced hypertension and metabolic disorder. Restoration of impaired BRS might be a potent target of therapeutic intervention in metabolic syndrome.