Open AccessDirect activation of tachykinin receptors within baroreflex afferent pathway and neurocontrol of blood pressure regulation
Author(s) -
Yuan Mei,
Ma MeiNa,
Wang TingYu,
Feng Yan,
Chen Pei,
He Chao,
Liu Sijie,
Guo YunXia,
Wang Yue,
Fan Yao,
Wang LuQi,
E XiaoQiang,
Qiao GuoFen,
Li BaiYan
Publication year - 2019
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12993
Subject(s) - baroreflex , microinjection , endocrinology , medicine , ovariectomized rat , substance p , baroreceptor , receptor , tachykinin receptor , chemistry , blood pressure , solitary nucleus , estrogen , neuropeptide , heart rate
Summary Aim Substance P ( SP ) causes vasodilation and blood pressure ( BP ) reduction. However, the involvement of tachykinin receptors ( NKR s) within baroreflex afferent pathway in SP ‐mediated BP regulation is largely unknown. Methods Under control and hypertensive condition, NKR s’ expressions were evaluated in nodose ( NG ) and nucleus of tractus solitary ( NTS ) of male, female, and ovariectomized ( OVX ) rats; BP was recorded after microinjection of SP and NKR s agonists into NG ; Baroreceptor sensitivity ( BRS ) was tested as well. Results Immunostaining and immunoblotting data showed that NK 1R and NK 2R were estrogen‐dependently expressed on myelinated and unmyelinated afferents in NG . A functional study showed that BP was reduced dose‐dependently by SP microinjection, which was more dramatic in males and can be mimicked by NK 1R and NK 2R agonists. Notably, further BP elevation and BRS dysfunction were confirmed in desoxycorticosterone acetate ( DOCA )‐salt model in OVX compared with DOCA ‐salt model in intact female rats. Additionally, similar changes in NKR s’ expression in NG were also detected using DOCA ‐salt and SHR . Compared with NG , inversed expression profiles of NKR s were also found in NTS with either gender. Conclusion The estrogen‐dependent NKR s’ expression in baroreflex afferent pathway participates at least partially in sexual‐dimorphic and SP ‐mediated BP regulation under physiological and hypertensive conditions.