Open AccessInhibition of Lats1/p‐ YAP 1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury
Author(s) -
Li Di,
Ji JiaXuan,
Xu YiTian,
Ni HaiBo,
Rui Qin,
Liu HuiXiang,
Jiang Feng,
Gao Rong,
Chen Gang
Publication year - 2018
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12833
Subject(s) - apoptosis , traumatic brain injury , neuroscience , phosphorylation , medicine , cerebral cortex , pharmacology , chemistry , biology , microbiology and biotechnology , biochemistry , psychiatry
Summary Aims To investigate the roles of Lats1/p‐ YAP 1 pathway in TBI ‐induced neuronal apoptosis and neurological deficits in rats. Results We found that Lats1 and YAP 1 were expressed in cerebral cortex neurons of Sprague‐Dawley rats, and the phosphorylation levels of Lats1 and YAP 1 in injured regions were significantly increased after TBI . Furthermore, inhibition of Lats1 not only decreased the level of p‐ YAP 1, but also attenuated neuronal apoptosis and neurological impairment. Conclusions Our work demonstrates that inhibition of Lats1/p‐ YAP 1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI .