Inhibition of Lats1/p‐ YAP 1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury | Zendy

Li Di | Zendy; Ji JiaXuan | Zendy; Xu YiTian | Zendy; Ni HaiBo | Zendy; Rui Qin | Zendy; Liu HuiXiang | Zendy; Jiang Feng | Zendy; Gao Rong | Zendy; Chen Gang | Zendy

Open Access

Inhibition of Lats1/p‐ YAP 1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury

Author(s) -

Li Di,

Ji JiaXuan,

Xu YiTian,

Ni HaiBo,

Rui Qin,

Liu HuiXiang,

Jiang Feng,

Gao Rong,

Chen Gang

Publication year - 2018

Publication title -

cns neuroscience and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.403

H-Index - 69

eISSN - 1755-5949

pISSN - 1755-5930

DOI - 10.1111/cns.12833

Subject(s) - apoptosis , traumatic brain injury , phosphorylation , neuroscience , cerebral cortex , medicine , chemistry , biology , microbiology and biotechnology , biochemistry , psychiatry

Summary Aims To investigate the roles of Lats1/p‐ YAP 1 pathway in TBI ‐induced neuronal apoptosis and neurological deficits in rats. Results We found that Lats1 and YAP 1 were expressed in cerebral cortex neurons of Sprague‐Dawley rats, and the phosphorylation levels of Lats1 and YAP 1 in injured regions were significantly increased after TBI . Furthermore, inhibition of Lats1 not only decreased the level of p‐ YAP 1, but also attenuated neuronal apoptosis and neurological impairment. Conclusions Our work demonstrates that inhibition of Lats1/p‐ YAP 1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI .

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