Open AccessFingolimod‐improved axonal and myelin integrity of white matter tracts associated with multiple sclerosis‐related functional impairments
Author(s) -
Gurevich Michael,
Waknin Roy,
Stone Evan,
Achiron Anat
Publication year - 2018
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12796
Subject(s) - fractional anisotropy , fingolimod , white matter , multiple sclerosis , diffusion mri , medicine , corticospinal tract , myelin , pyramidal tracts , expanded disability status scale , neuroscience , psychology , magnetic resonance imaging , radiology , central nervous system , psychiatry
Summary Aims Fingolimod hydrochloride is an effective immunomodulatory drug in improving relapsing‐remitting multiple sclerosis (RRMS). However, data on the neuroradiologic effects on white matter (WM) have not been demonstrated. In this study, we aimed elucidating the impact of 1‐year fingolimod treatment on WM integrity in patients with RRMS. Methods Diffusion tensor imaging (DTI) was applied to assess axonal and myelin integrity in specific WM tracts of patients with RRMS prior to and 1 year postfingolimod treatment (n = 30). The fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity, and mean diffusivity were analyzed using tract‐based spatial statistics on specific regions of interest associated with impaired Expanded Disability Status Scale functional scores before treatment. Results In patients with impaired pyramidal function at baseline (average score 2.3 ± 0.2, n = 25), fingolimod induced a significant increase in FA ( P = 0.002) and decrease in RD ( P = 0.03) in the corticospinal tract. In patients with impaired cerebellar function at baseline (average score 2.0 ± 0.1, n = 19), significant increases in FA and decreases in RD were observed in the superior ( P = 0.02, P = 0.01, respectively) and inferior ( P = 0.03, P = 0.05, respectively) cerebellar peduncles. Conclusion The observed results suggest increased microstructural integrity and decreased demyelination of damaged WM tracts and support the possible direct mechanism of fingolimod action.