Open AccessAdvances in chronic cerebral circulation insufficiency
Author(s) -
Zhou Da,
Meng Ran,
Li SiJie,
Ya JingYuan,
Ding JiaYue,
Shang ShuLing,
Ding YuChuan,
Ji XunMing
Publication year - 2018
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12780
Subject(s) - etiology , medicine , cerebral circulation , dementia , intensive care medicine , disease , cerebral blood flow , stroke (engine) , epidemiology , presentation (obstetrics) , pathophysiology , bioinformatics , neuroscience , cardiology , pathology , surgery , psychology , biology , mechanical engineering , engineering
Summary Chronic cerebral circulation insufficiency ( CCCI ) may not be an independent disease; rather, it is a pervasive state of long‐term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress of CCCI , mainly focusing on epidemiology, experimental research, pathophysiology, etiology, clinical manifestations, imaging presentation, diagnosis, and potential therapeutic regimens. Some research directions are briefly discussed as well.