Open AccessEnlarged perivascular spaces are associated with health‐related quality of life in patients with acute ischemic stroke
Author(s) -
Liang Yan,
Deng Min,
Chen YangKun,
Mok Vincent,
Wang DeFeng,
Ungvari Gabor S.,
Chu ChiuWing Winnie,
Berge Eivind,
Tang WaiKwong
Publication year - 2017
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12766
Subject(s) - stroke (engine) , medicine , basal ganglia , lacunar stroke , quality of life (healthcare) , brain ischemia , acute stroke , cardiology , physical therapy , ischemic stroke , ischemia , central nervous system , mechanical engineering , nursing , engineering , tissue plasminogen activator
Summary Aims This study explored the association between enlarged perivascular spaces ( EPVS ) and the health‐related quality of life ( HRQ oL) in patients with acute ischemic stroke. Methods This was an observational study of consecutively screened patients with acute ischemic stroke from March 2010 to March 2015. EPVS were rated in the basal ganglia and the centrum semiovale with a validated scale. The HRQ oL was assessed 3 months after the stroke onset using the Stroke‐Specific Quality of Life ( SSQ oL). Linear regression models were used to study the association between EPVS and HRQ oL. Results The study included 648 patients (mean age 65.8 years; 40.0% women) with mild to moderately severe stroke (median NIHSS score 2), of whom 640 (98.8%) exhibited signs of small vessel disease. The median EPVS scores in the basal ganglia and the centrum semiovale were 1 each. In linear regression analysis, EPVS in the basal ganglia were associated with a lower total SSQ oL score ( P = 0.02) and lower mobility ( P = 0.01), mood ( P = 0.03), and self‐care ( P < 0.01). EPVS in the centrum semiovale were associated only with a lower SSQ oL work/productivity subscore ( P = 0.002). Conclusions EPVS are associated with lower HRQ oL in patients with mild to moderate acute ischemic stroke. Early identification and intervention of EPVS may improve HRQ oL in stroke survivors.