Open AccessOrganoid technology for brain and therapeutics research
Author(s) -
Wang Zhi,
Wang ShuNa,
Xu TianYing,
Miao ZhuWei,
Su DingFeng,
Miao ChaoYu
Publication year - 2017
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12754
Subject(s) - organoid , neuroscience , induced pluripotent stem cell , human brain , regenerative medicine , drug discovery , personalized medicine , brain research , biology , medicine , stem cell , bioinformatics , embryonic stem cell , microbiology and biotechnology , biochemistry , gene
Summary Brain is one of the most complex organs in human. The current brain research is mainly based on the animal models and traditional cell culture. However, the inherent species differences between humans and animals as well as the gap between organ level and cell level make it difficult to study human brain development and associated disorders through traditional technologies. Recently, the brain organoids derived from pluripotent stem cells have been reported to recapitulate many key features of human brain in vivo, for example recapitulating the zone of putative outer radial glia cells. Brain organoids offer a new platform for scientists to study brain development, neurological diseases, drug discovery and personalized medicine, regenerative medicine, and so on. Here, we discuss the progress, applications, advantages, limitations, and prospects of brain organoid technology in neurosciences and related therapeutics.