Open AccessAntidepressant‐like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus
Author(s) -
Wang Hao,
Zhao Ying,
Wang YingJie,
Song Lu,
Wang JinLiang,
Huang Chao,
Zhang Wei,
Jiang Bo
Publication year - 2017
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12708
Subject(s) - behavioural despair test , tail suspension test , antidepressant , neurotrophic factors , hippocampal formation , neurogenesis , neuroprotection , brain derived neurotrophic factor , pharmacology , hippocampus , neuroscience , psychology , medicine , receptor
Summary Background and Aims Current antidepressants in clinic need weeks of administration and always have significant limitations. Tetrahydroxystilbene glucoside (TSG) is one of the major bioactive ingredients of Polygonum multiflorum with neuroprotective effects. This study aimed to evaluate the antidepressant effects of TSG in mice. Methods The antidepressant‐like effects of TSG in mice were examined in the forced swim test (FST), tail suspension test (TST), and chronic social defeat stress (CSDS) model of depression. The effects of CSDS and TSG on the hippocampal brain‐derived neurotrophic factor (BDNF) signaling pathway and neurogenesis were further investigated. Moreover, the pharmacological inhibitors and lentiviral‐shRNA were used to explore the antidepressant mechanisms of TSG. Results TSG produced antidepressant‐like effects in the FST and TST and also reversed the CSDS‐induced depressive‐like symptoms. Moreover, TSG treatment significantly restored the decreased hippocampal BDNF signaling pathway and neurogenesis in CSDS mice. Importantly, blockade of the hippocampal BDNF system fully abolished the antidepressant‐like effects of TSG in mice. Conclusion In conclusion, TSG produces antidepressant‐like effects in mice via enhancement of the hippocampal BDNF system.