Open AccessTerapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease
Author(s) -
Luca Giovanni,
Bellezza Ilaria,
Arato Iva,
Di Pardo Alba,
Mancuso Francesca,
Calvitti Mario,
Falabella Giulia,
Bartoli Sara,
Maglione Vittorio,
Amico Enrico,
Favellato Mariagrazia,
Basta Giuseppe,
Bodo Maria,
Minelli Alba,
Calafiore Riccardo,
Frati Luigi,
Squitieri Ferdinando
Publication year - 2016
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12569
Subject(s) - huntington's disease , sertoli cell , neurodegeneration , immune system , disease , intraperitoneal injection , medicine , neuroscience , endocrinology , biology , immunology , spermatogenesis
Summary Introduction Immune dysfunction, promoted by pro‐inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.