Open AccessNeuropsychological and Neuroimaging Characteristics of Amnestic Mild Cognitive Impairment Subtypes: A Selective Overview
Author(s) -
Li Xin,
Zhang ZhanJun
Publication year - 2015
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12391
Subject(s) - neuroimaging , neuropsychology , neuroscience , psychology , cognition , cognitive impairment , disease , functional neuroimaging , medicine , pathology
Summary Alzheimer's disease ( AD ) is a progressive age‐related neurodegenerative disease. Amnestic mild cognitive impairment ( aMCI ) is considered to represent early AD . Various aMCI clinical subtypes have been identified as either single domain ( SD ) or multidomain ( MD ). The various subtypes represent heterogeneous syndrome, indicating the different probability of progression to AD . Understanding the heterogeneous concept of aMCI can help to construct potential biomarkers to monitor the progression of aMCI to AD . This review provides an overview of various neuroimaging measures for subtypes of aMCI . Focusing on neuropsychological, structural, and functional neuroimaging findings, we found that aMCI showed differences in clinical progression and the abnormalities in MD ‐ aMCI were distributed across temporal, frontal, and parietal cortices, which is similar to AD . This is also compatible with the notion that MD ‐ aMCI is a transition stage between SD ‐ aMCI and AD . Our review provided a framework for the diagnosis of clinical subtypes of aMCI and early detection and intervention of the progression from aMCI to AD.