Open AccessFunction of Nogo‐A/Nogo‐A Receptor in Alzheimer's Disease
Author(s) -
Xu YingQi,
Sun ZhongQing,
Wang YiTao,
Xiao Fei,
Chen MeiWan
Publication year - 2015
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12387
Subject(s) - neuroscience , disease , receptor , pathogenesis , alzheimer's disease , function (biology) , regeneration (biology) , medicine , biology , microbiology and biotechnology , immunology , pathology
Summary Nogo‐A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo‐A in Alzheimer's disease in the past decade. Recent research shows that through binding to Nogo‐A receptor, Nogo‐A plays an important role in Alzheimer's disease ( AD ) pathogenesis. Particularly, Nogo‐A/Nogo‐A receptors modulate the generation of amyloid β ‐protein (A β ), which is thought to be a major cause of AD . This review describes the recent development of Nogo‐A, Nogo‐A receptor, and downstream signaling involved in AD and pharmacological basis of therapeutic drugs. We concluded the Nogo‐A/Nogo‐A receptor provide new insight into potential mechanisms and promising therapy strategies in AD .