Open AccessDepolarizing GABA and Developmental Epilepsies
Author(s) -
Khazipov Roustem,
Valeeva Guzel,
Khalilov Ilgam
Publication year - 2015
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12353
Subject(s) - depolarization , neuroscience , excitatory postsynaptic potential , inhibitory postsynaptic potential , gabaa receptor , hyperpolarization (physics) , biology , chemistry , endocrinology , receptor , biochemistry , organic chemistry , nuclear magnetic resonance spectroscopy
Summary Early in development, GABA , which is the main inhibitory neurotransmitter in adult brain, depolarizes immature neurons and exerts dual—excitatory and shunting/inhibitory—effects in the developing neuronal networks. The present review discusses some general questions, including the properties of excitation at depolarizing GABA ergic synapse and shunting inhibition by depolarizing GABA ; technical issues in exploration of depolarizing GABA using various techniques and preparations, including the developmental aspects of traumatic injury and what is known (or rather unknown) on the actions of GABA in vivo ; complex roles of depolarizing GABA in developmental epilepsies, including a contribution of depolarizing GABA to enhanced excitability in the immature networks, caused by repetitive seizures accumulation of intracellular chloride concentration that increases excitatory GABA power and its synchronizing proconvulsive effects, and correction of chloride homeostasis as a potential strategy to treat neonatal seizures.