Open AccessChanges in Metabolites after Treatment with Memantine in Fibromyalgia. A Double‐Blind Randomized Controlled Trial with Magnetic Resonance Spectroscopy with a 6‐month Follow‐up
Author(s) -
Fayed Nicolás,
OlivanBlázquez Bárbara,
HerreraMercadal Paola,
PueblaGuedea Marta,
PérezYus MariCruz,
Andrés Eva,
López del Hoyo Yolanda,
Magallon Rosa,
Viguera Laura,
GarciaCampayo Javier
Publication year - 2014
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12314
Subject(s) - memantine , creatine , fibromyalgia , placebo , medicine , randomized controlled trial , glutamate receptor , posterior cingulate , metabolite , choline , anesthesia , nmda receptor , psychology , psychiatry , cognition , pathology , alternative medicine , receptor
Summary Aim To evaluate the efficacy of memantine on metabolite levels in different areas of the brain and to determine whether changes in metabolite levels correlate with clinical variables in Fibromyalgia ( FM ) patients. Methods Doubled‐blind parallel randomized controlled trial. Twenty‐five patients diagnosed with FM were enrolled in the study. Patients were administered questionnaires on pain, anxiety, depression, quality of life, and cognitive impairment, and single‐voxel MRS of the brain was performed. All assessments were performed at baseline and after 6 months of treatment with memantine or placebo. Results Patients treated with memantine exhibited a significant increase in the glutamate ( P = 0.010), glutamate/creatine ratio ( P = 0.013), combined glutamate + glutamine ( P = 0.016) and total N ‐acetyl‐aspartate ( NAA + NAAG ) ( P = 0.034) in the posterior cingulate cortex compared with those on placebo. Furthermore, the memantine group exhibited increases in creatine ( P = 0.013) and choline (Cho) ( P = 0.025) in the right posterior insula and also a correlation between choline and the Fibromyalgia Impact Questionnaire ( FIQ ) in the posterior insula ( P = 0.050) was observed. Conclusion Memantine treatment resulted in an increase in cerebral metabolism in FM patients, suggesting its utility for the treatment of the illness.