Open AccessQuetiapine Fumarate for the Treatment of Multiple Sclerosis: Focus on Myelin Repair
Author(s) -
Zhornitsky Simon,
Wee Yong Voon,
Koch Marcus W.,
Mackie Aaron,
Potvin Stéphane,
Patten Scott B.,
Metz Luanne M.
Publication year - 2013
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12154
Subject(s) - neuroprotection , multiple sclerosis , medicine , dimethyl fumarate , neuroscience , quetiapine , oligodendrocyte , tolerability , microglia , experimental autoimmune encephalomyelitis , glatiramer acetate , neurodegeneration , myelin , immunology , pharmacology , central nervous system , psychology , pathology , inflammation , schizophrenia (object oriented programming) , psychiatry , adverse effect , disease
Summary Multiple sclerosis ( MS ) is a central nervous system disorder that is associated with progressive oligodendrocyte and neuronal loss, axonal degeneration, and demyelination. Several medications that mitigate immune abnormalities reduce both the frequency of relapses and inflammation on magnetic resonance imaging, leading to improved outcomes for people with the relapsing–remitting form of MS . However, there are no treatments for the progressive forms of MS where neurons and axons continue to degenerate; here, neuroprotective therapies, or medications that rebuild myelin to confer axonal well‐being, may be useful. Quetiapine fumarate is an atypical antipsychotic with reported remyelinating and neuroprotective properties in inflammatory and noninflammatory models of demyelination, including experimental autoimmune encephalomyelitis, and both cuprizone‐ and global cerebral ischemia‐induced demyelination. Preclinical studies suggest that quetiapine may exert these effects by stimulating proliferation and maturation of oligodendrocytes, releasing neurotrophic factors, increasing antioxidant defences, scavenging for free radicals, and inhibiting activated microglia, astrocytes, and T lymphocytes. Additionally, quetiapine may be beneficial for psychiatric and nonpsychiatric symptoms of MS including depression, anxiety, insomnia, and possibly even pain. These data indicate that clinical trials are justified to determine the safety, tolerability, and efficacy of quetiapine fumarate in MS .