Open AccessOctodon degus : A Model for the Cognitive Impairment Associated with A lzheimer's Disease
Author(s) -
Tarragon Ernesto,
Lopez Dolores,
Estrada Cristina,
Ana GonzalezCuello,
Schenker Esther,
Pifferi Fabien,
Bordet Regis,
Richardson Jill C.,
Herrero Maria Trinidad
Publication year - 2013
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12125
Subject(s) - cognitive impairment , disease , cognition , rodent , neuroscience , psychology , biology , medicine , pathology , ecology
Summary Octodon degus ( O . degus ) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O . degus has recently been identified as a very valuable animal model for research in several medical fields, especially those concerned with neurodegenerative diseases in which risk is associated with aging. Octodon degus spontaneously develops β‐amyloid deposits analogous to those observed in some cases of A lzheimer's disease ( AD ). Moreover, these deposits are thought to be the key feature for AD diagnosis, and one of the suggested causes of cell loss and cognitive deficit. This review aims to bring together information to support O . degus as a valuable model for the study of AD .