Open AccessTelemetric Ambulatory Arterial Stiffness Index, a Predictor of Cardio–Cerebro–Vascular Mortality, is Associated with Aortic Stiffness‐Determining Factors
Author(s) -
Li ZhiYong,
Xu TianYing,
Zhang SaiLong,
Zhou XiaoMing,
Xu XueWen,
Guan YunFeng,
Lo Ming,
Miao ChaoYu
Publication year - 2013
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12120
Subject(s) - arterial stiffness , cardiology , pulse pressure , medicine , blood pressure , ambulatory , pulse wave velocity , elastin , ambulatory blood pressure , pathology
Summary Background Ambulatory arterial stiffness index ( AASI ) has been proposed as a new measure of arterial stiffness for predicting cardio–cerebro–vascular morbidity and mortality. However, there has been no research on the direct relationships between AASI and arterial stiffness‐determining factors. Methods We utilized beat‐to‐beat intra‐aortic blood pressure ( BP ) telemetry to characterize AASI in Wistar–Kyoto ( WKY ) and spontaneously hypertensive rats ( SHR ). By determination of aortic structural components and analysis of their correlations with AASI , we provided the first direct evidence for the associations between AASI and arterial stiffness‐determining factors including the collagen content and collagen/elastin. Results Ambulatory arterial stiffness index was positively correlated with pulse pressure in both WKY and SHR , less dependent on BP and BP variability than pulse pressure, and relatively stable, especially the number of BP readings not less than ~36. The correlations between AASI and aortic components were comparable for various AASI values derived from BP readings not less than ~36. Not only AASI but also BP variability and pulse pressure demonstrated a direct relationship with arterial stiffness. Conclusions These findings indicate AASI may become a routine measure in human arterial stiffness assessment. It is recommended to use a cluster of parameters such as AASI , BP variability, and pulse pressure for evaluating arterial stiffness.