Open AccessOxidative Stress is not Involved in Motion Sickness in Mice
Author(s) -
Wang ZhiBin,
Han Ping,
Tu Ye,
Liu WeiYe,
Tao BeiLei,
Zhang LiChao,
Li Ling
Publication year - 2013
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12115
Subject(s) - oxidative stress , motion sickness , superoxide dismutase , catalase , antioxidant , reactive oxygen species , vitamin e , chemistry , vitamin c , medicine , biochemistry , psychiatry
Summary Aims Some indirect evidences indicate a possible correlation between oxidative stress and motion sickness. The aim of this research was to investigate whether oxidative stress contributing to motion sickness in mice or not. Methods We examined the mRNA levels of peroxiredoxin 6 (PRDX6), catalase, and enzyme superoxide dismutase 1 (SOD1); reactive oxygen species (ROS); and total antioxidant capacity and SOD activity in different brain regions after rotary stimulation. Mice motion sickness index was recorded after rotation when pretreated with paraquat, vitamin C, or vitamin E. Results The ROS level and antioxidant capacity were both increased in cerebellum plus brainstem ( CB ) after rotation, a critical region determines motion sickness. However, manipulation of oxidants or antioxidants using pharmacological method in vivo had no influence on motion sickness index in mice. Conclusion Oxidative stress is not involved in the development of motion sickness in mice.