Open AccessKetamine and Peripheral Inflammation
Author(s) -
Kock Marc,
Loix Sebastien,
Lavand'homme Patricia
Publication year - 2013
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12104
Subject(s) - ketamine , mechanism (biology) , neuroscience , medicine , inflammation , inflammatory response , peripheral , immune system , intensive care medicine , bioinformatics , psychology , immunology , biology , philosophy , epistemology
Summary The old anesthetic ketamine has demonstrated interactions with the inflammatory response. This review intends to qualify the nature and the mechanism underlying this interaction. For this purpose, preclinical data will be presented starting with the initial works, and then, the probable mechanisms will be discussed. A summary of the most relevant clinical data will be presented. In conclusion, ketamine appears as a unique “homeostatic regulator” of the acute inflammatory reaction and the stress‐induced immune disturbances. This is of some interest at a moment when the short‐ and long‐term deleterious consequences of inadequate inflammatory reactions are increasingly reported. Large‐scale studies showing improved patient's outcome are, however, required before to definitively assert the clinical reality of this positive effect.