Open AccessThrombolysis on Ischemic Stroke Patients with Decreased Level of Consciousness within 4.5 h
Author(s) -
Chen Cong,
Ye Min,
Chen BeiLei,
Chen GuoFang,
Gao ZhiQiang,
Zhou JunShan,
Cheng QianTao,
Wu MingHua,
Zhang MeiJuan,
Qian Lai,
Xu Yun
Publication year - 2013
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12030
Subject(s) - medicine , thrombolysis , glasgow coma scale , modified rankin scale , level of consciousness , stroke (engine) , intracerebral hemorrhage , tissue plasminogen activator , coma (optics) , ischemic stroke , anesthesia , ischemia , myocardial infarction , mechanical engineering , physics , optics , engineering
Summary Background and purpose Few reports concerned on recombinant tissue plasminogen activator (rt‐ PA ) treatment in stroke patients with decreased consciousness. This study assesses the efficacy and safety of intravenous rt‐ PA administration within 4.5 h in stroke patients with decreased consciousness. Methods A total of 136 stroke patients with decreased consciousness, who received or not rt‐ PA intravenously within 4.5 h after stroke onset from J iangsu province of C hina from 2009 to 2012, were reviewed retrospectively. G lasgow C oma S cale ( GCS ), N ational I nstitute of H ealth S troke S cale ( NIHSS ), intracranial hemorrhage rate, and mortality were used to determine patient outcome when discharged. A 3‐month outcome was calculated by modified R ankin S cale ( mRS ) with score 0 to 1 considered favorable outcome. Results Baseline characteristics of two groups were similar. When discharged, no significant differences were observed regarding NIHSS score ( P = 0.994) or GCS score ( P = 0.591) between groups. After 3 months, 22.8% patients in rt‐ PA group had favorable outcome as compared with 7.5% patients in control group ( P = 0.014). Treatment with rt‐ PA did not significantly increase incidence of hemorrhage ( P = 0.494) or mortality ( P = 0.169). Conclusions Intravenous rt‐ PA administration within 4.5 h after onset of symptoms benefited stroke patients with abnormal consciousness.