Open AccessOrgan‐on‐chip to investigate host‐pathogens interactions
Author(s) -
Feaugas Thomas,
Sauvonnet Nathalie
Publication year - 2021
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.13336
Subject(s) - biology , host (biology) , microfluidics , organ on a chip , pathogen , computational biology , nanotechnology , ecology , immunology , materials science
Infectious diseases remain the subject of intense research. This topic reaches a new era towards the study of host‐pathogen interactions mechanisms at the tissue scale. The past few years have hence witnessed the emergence of new methods. Among them, organ‐on‐chip, which combines biomaterial technology, microfluidic and tissue engineering to recreate the organ physiology is very promising. This review summarises how this technology recapitulates the architecture, the mechanical stimulation and the interface of a tissue and how this particular microenvironment is critical to study host‐pathogen interactions.