Open AccessSphingosine‐1‐phosphate receptors and innate immunity
Author(s) -
Bryan Arielle M.,
Del Poeta Maurizio
Publication year - 2018
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12836
Subject(s) - biology , innate immune system , signalling , sphingosine 1 phosphate , microbiology and biotechnology , receptor , sphingosine , sphingosine 1 phosphate receptor , acquired immune system , immunity , signal transduction , lipid signaling , immune system , signalling pathways , neuroscience , immunology , biochemistry
Abstract Sphingosine‐1‐phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well‐studied role of S1P signalling is to modulate T‐cell trafficking, which has a major impact on adaptive immunity. Compounds that target S1P signalling pathways are of interest for immune system modulation. Recent studies suggest that S1P signalling regulates many more cell types and processes than previously appreciated. This review will summarise current understanding of S1P signalling, focusing on recent novel findings in the roles of S1P receptors in innate immunity.