Open AccessListeria monocytogenes cytosolic metabolism promotes replication, survival, and evasion of innate immunity
Author(s) -
Chen Grischa Y.,
Pensinger Daniel A.,
Sauer JohnDemian
Publication year - 2017
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12762
Subject(s) - biology , listeria monocytogenes , innate immune system , cytosol , intracellular , immunity , intracellular parasite , immune system , microbiology and biotechnology , programmed cell death , bacteria , immunology , genetics , apoptosis , biochemistry , enzyme
Summary Listeria monocytogenes , the causative agent of listeriosis, is an intracellular pathogen that is exquisitely evolved to survive and replicate in the cytosol of eukaryotic cells. Eukaryotic cells typically restrict bacteria from colonising the cytosol, likely through a combination of cell autonomous defences, nutritional immunity, and innate immune responses including induction of programmed cell death. This suggests that L. monocytogenes and other professional cytosolic pathogens possess unique metabolic adaptations, not only to support replication but also to facilitate resistance to host‐derived stresses/defences and avoidance of innate immune activation. In this review, we outline our current understanding of L. monocytogenes metabolism in the host cytosol and highlight major metabolic processes which promote intracellular replication and survival.