Open AccessInflammasome activators induce fibronectin expression and release in macrophages
Author(s) -
Jun HyeKyoung,
Jung YoungJung,
Choi BongKyu
Publication year - 2017
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12695
Subject(s) - inflammasome , microbiology and biotechnology , biology , fibronectin , secretion , programmed cell death , aim2 , extracellular , caspase 1 , pyroptosis , apoptosis , caspase , signal transduction , inflammation , immunology , extracellular matrix , biochemistry
Extracellular fibronectin (Fn) can activate pro‐inflammatory pathways and serves as an endogenous danger signalling molecule; thus, it has been suggested as a biomarker for several diseases. In the present study, we found that pathogen‐derived activators of the inflammasomes induce the expression and secretion of Fn in macrophages through a mechanism involving adenosine triphosphate and caspase‐1 activation. We also found that plasma Fn induces caspase‐1 activation and cell death in macrophages, epithelial cells, and fibroblasts. Together, these results indicate that Fn plays a critical role in inflammasome‐activated cells by amplifying caspase‐1 activation and inducing inflammatory cell death.