Open AccessThe innate immune response in human tuberculosis
Author(s) -
Lerner Thomas R.,
Borel Sophie,
Gutierrez Maximiliano G.
Publication year - 2015
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12480
Subject(s) - biology , innate immune system , immune system , mycobacterium tuberculosis , acquired immune system , tuberculosis , immunology , clearance , immunity , virology , medicine , pathology , urology
Summary M ycobacterium tuberculosis ( Mtb ) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini‐review, we discuss these host–pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome‐wide association studies).