Open AccessCommensals, probiotics and pathogens in the C aenorhabditis elegans model
Author(s) -
Clark Laura C.,
Hodgkin Jonathan
Publication year - 2014
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12234
Subject(s) - biology , commensalism , caenorhabditis elegans , host (biology) , bacillus subtilis , probiotic , bacteria , microbiology and biotechnology , escherichia coli , bacillus (shape) , microorganism , genetics , gene
Summary C aenorhabditis elegans is a useful model host for a wide variety of microorganisms that have implications for human health. Recent surveys of mammalian and metazoan microbiota demonstrate the often profound effects of gut commensal bacteria on host lifespan, health and development. Work using C . elegans has revealed the surprising extent to which bacterial metabolism can interact with host pathways with examples from E scherichia coli folate metabolism and B acillus subtilis nitric oxide synthesis. The C . elegans model has also shed light on the mechanisms by which probiotic bacteria influence lifespan.