Open AccessCommensal bacteria‐dependent select expression of CXCL 2 contributes to periodontal tissue homeostasis
Author(s) -
Zenobia Camille,
Luo Xiao Long,
Hashim Ahmed,
Abe Toshiharu,
Jin Lijian,
Chang Yucheng,
Jin Zhi Chao,
Sun Jian Xun,
Hajishengallis George,
Curtis Mike A.,
Darveau Richard P.
Publication year - 2013
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12127
Subject(s) - cxcl2 , biology , cxcl1 , chemokine , microbiology and biotechnology , cxc chemokine receptors , immunology , microbiome , chemotaxis , inflammation , chemokine receptor , receptor , bioinformatics , genetics
Summary The oral and intestinal host tissues both carry a heavy microbial burden. Although commensal bacteria contribute to healthy intestinal tissue structure and function, their contribution to oral health is poorly understood. A crucial component of periodontal health is the recruitment of neutrophils to periodontal tissue. To elucidate this process, gingival tissues of specific‐pathogen‐free and germ‐free wild‐type mice and CXCR 2 KO and MyD 88 KO mice were examined for quantitative analysis of neutrophils and CXCR 2 chemoattractants ( CXCL 1, CXCL 2). We show that the recruitment ofneutrophils to the gingival tissue does not require commensal bacterial colonization but is entirely dependent on CXCR 2 expression. Strikingly, however, commensal bacteria selectively upregulate the expression of CXCL 2, but not CXCL 1, in a MyD 88‐dependent way that correlates with increased neutrophil recruitment as compared with germ‐free conditions. This is the first evidence that the selective use of chemokine receptor ligands contributes to neutrophil homing to healthy periodontal tissue.