Open AccessDysfunctions at human intestinal barrier by water‐borne protozoan parasites: lessons from cultured human fully differentiated colon cancer cell lines
Author(s) -
LiévinLe Moal Vanessa
Publication year - 2013
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12126
Subject(s) - biology , intestinal epithelium , microbiology and biotechnology , cell , virulence , giardia , cell culture , epithelium , pathogenesis , entamoeba , colorectal cancer , entamoeba histolytica , cancer , immunology , gene , genetics
Summary Some water‐borne protozoan parasites induce diseases through their membrane‐associated functional structures and virulence factors that hijack the host cellular molecules and signalling pathways leading to structural and functional lesions in the intestinal barrier. In this M icroreview we analyse the insights on the mechanisms of pathogenesis of E ntamoeba intestinalis , G iardia and C ryptosporidium observed in the human colon carcinoma fully differentiated colon cancer cell lines, cell subpopulations and clones expressing the structural and functional characteristics of highly specialized fully differentiated epithelial cells lining the intestinal epithelium and mimicking structurally and functionally an intestinal barrier.