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Resveratrol reverses the negative effect of smoking on peri‐implant repair in the tibia of rats
Author(s) -
Ribeiro Fernanda Vieira,
Pimentel Suzana Peres,
Corrêa Monica Grazieli,
Bortoli João Paulo,
Messora Michel Reis,
Casati Marcio Zaffalon
Publication year - 2019
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.13384
Subject(s) - implant , medicine , tibia , dentistry , placebo , resveratrol , dental implant , anesthesia , surgery , pathology , pharmacology , alternative medicine
Objectives Innovative approaches capable to improve peri‐implant bone repair are relevant in the presence of smoking, a risk factor for healing around implants. This study investigated the effect of resveratrol (RESV) on peri‐implant repair, and its influence on bone‐related markers in rats submitted to cigarette smoking inhalation (CSI). Materials and methods One titanium implant was inserted in each tibiae of rats assigned to CSI+RESV (n:18); CSI+placebo (n:18); and non‐CSI (n:18). One implant was removed for counter torque, and the peri‐implant tissue was collected for mRNA quantification of BMP‐2, OPN, Runx2, Lrp‐5, Osx, β‐catenin, Dkk1, OPG, and RANKL. The other tibia was submitted to microCT to measure: bone volume, bone porosity, trabecular spacing, trabecular thickness, and bone‐implant contact (BIC). Results No differences were detected between counter torque in CSI+RESV and non‐CSI group ( p > 0.05), whereas CSI+placebo group presented lower values when compared to the others ( p < 0.05). RESV improved the BIC in CSI rats without differences when compared to non‐CSI group ( p > 0.05), whereas CSI+placebo showed reduced BIC when compared to the other groups ( p < 0.05). RESV reduced RANKL/OPG and Lrp‐5 levels and increased β‐catenin in CSI rats when compared to CSI+placebo ( p < 0.05). Conclusion Although further investigations should be considered using oral models of dental implants, within the limits of the present study, it was concluded that RESV reverses the negative effects of smoking in the peri‐implant repair, benefiting the modulation of bone‐related markers.