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Anti‐resorptive effect of pamidronate on extraction socket wall in dogs
Author(s) -
Cha JaeKook,
Sun YooKyung,
Kim Myong Ji,
Sanz Mariano,
Jung UiWon
Publication year - 2018
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.13260
Subject(s) - buccal administration , dentistry , crest , extraction (chemistry) , saline , medicine , matrix (chemical analysis) , orthodontics , chemistry , physics , chromatography , quantum mechanics
Abstract Aim The aim of this experimental in vivo investigation was to assess the anti‐resorptive effect of low concentration pamidronate on the buccal plate in fresh extraction sockets. Materials and methods The distal roots of the third premolars were extracted bilaterally in six dogs. A collagen matrix loaded with either pamidronate (test group) or saline (control group) was positioned on the outer surface of buccal bone immediately after tooth extraction and subsequently covered with a coronally advanced flap. Histological and histomorphometric outcomes were evaluated 12 weeks later. Results The mean vertical distance between the buccal and lingual bone crest differed significantly between the test and control groups (0.52 ± 0.43 and 2.21 ± 1.15 mm, respectively; p = .037). The width of the buccal bone 1 mm below the crest was significantly wider in the test group than the control group (4.68 ± 0.68 vs. 3.44 ± 0.60 mm, p < .001). Conclusions Local application of pamidronate onto a collagen matrix may reduce the dimensional changes of the buccal bone plate both vertically and horizontally.