Premium
Injectable, compression‐resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model
Author(s) -
Talley Anne D.,
Boller Lauren A.,
Kalpakci Kerem N.,
Shimko Daniel A.,
Cochran David L.,
Guelcher Scott A.
Publication year - 2018
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.13257
Subject(s) - ridge , compression (physics) , biomedical engineering , bone healing , materials science , dentistry , medicine , anatomy , nuclear medicine , composite material , biology , paleontology
Abstract Objective The objective of this study was to test the hypothesis that a compression‐resistant bone graft augmented with recombinant human morphogenetic protein‐2 (rhBMP‐2) will promote lateral ridge augmentation without the use of protective mesh in a canine model. Materials & Methods Compression‐resistant (CR) bone grafts were evaluated in a canine model of lateral ridge augmentation. Bilateral, right trapezoidal prism‐shaped defects (13–14 mm long × 8–9 mm wide × 3–4 mm deep at the base) in 13 hounds (two defects per hound) were treated with one of four groups: (i) absorbable collagen sponge + 400 μg rhBMP‐2/ml (ACS, clinical control) protected by titanium mesh, (ii) CR without rhBMP‐2 (CR, negative control), (iii) CR + 200 μg rhBMP‐2 (CR‐L), or (iv) CR + 400 μg rhBMP‐2 (CR‐H). All animals were euthanized after 16 weeks. Ridge height and width and new bone formation were assessed by μCT, histology, and histomorphometry. The release kinetics of rhBMP‐2 from CR bone grafts in vitro and in vivo in a femoral condyle defect model in rabbits was also evaluated. Results All four bone grafts promoted new bone formation (11–31.6 volume%) in the lateral ridge defects. For CR grafts, ridge height and width increased in a dose‐responsive manner with increasing rhBMP‐2 concentration. Ridge height and width measured for CR‐H without the use of protective mesh was comparable to that measured for ACS with a protective mesh. Conclusions At the same dose of rhBMP‐2, an injectable, compression‐resistant bone graft resulted in a comparable volume of new bone formation with the clinical control (ACS). These findings highlight the potential of compression‐resistant bone grafts without the use of protective mesh for lateral ridge augmentation.