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Report of a human autopsy case in maxillary sinuses augmented using a synthetic bone substitute: Micro‐computed tomographic and histologic observations
Author(s) -
Lee JungSeok,
Cha JaeKook,
Thoma Daniel S.,
Jung UiWon
Publication year - 2018
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.13124
Subject(s) - maxillary sinus , sinus (botany) , medicine , implant , osseointegration , dentistry , surgery , botany , biology , genus
Objective This study of a human autopsy case aimed to characterize the histologic and micro‐computed tomographic results of maxillary sinus augmentation using a synthetic bone substitute and simultaneous implant placement at 6 years. Material and methods This report is based on the whole‐body donation of a 62‐year‐old male patient who died due to bladder cancer. Implants had been placed in conjunction with sinus augmentation using a mixture of biphasic calcium phosphate and autogenous bone into both maxillary sinuses 6 years prior to the body donation. The maxillary sinus areas containing implants were gently removed from the cadaver and scanned using high‐resolution micro‐computed tomography. Samples were sectioned, prepared for undecalcified histologic slides and stained with haematoxylin‐eosin. Results The augmented volume was observed up to the apex of the implants, which were successfully osseointegrated. Cross‐sectional micro‐computed tomographic views revealed that the bone‐substitute particles were embedded in radiopaque‐mineralized tissues showing a trabecular pattern around the implants. The histologic analysis revealed mature lamellar bone surrounding the remaining bone‐substitute particles as well as well‐organized bone marrow spaces in the augment bone area and around the dental implants. Conclusion This human autopsy study histologically confirmed the presence of successful bone formation and long‐term volume stability after sinus augmentation using biphasic calcium phosphate and simultaneous implant placement.