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Guided bone regeneration with particulate vs. block xenogenic bone substitutes: a pilot cone beam computed tomographic investigation
Author(s) -
Benic Goran I.,
Thoma Daniel S.,
Jung Ronald E.,
Sanz-Martin Ignacio,
Unger Silvan,
Cantalapiedra Antonio,
Hämmerle Christoph H.F.
Publication year - 2017
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.13011
Subject(s) - cone beam computed tomography , soft tissue , implant , biomedical engineering , mandible (arthropod mouthpart) , computed tomographic , dentistry , nuclear medicine , materials science , medicine , computed tomography , surgery , botany , biology , genus
Aim To test whether an equine bone substitute block used for guided bone regeneration ( GBR ) of peri‐implant defects differs from bovine block or particulate bone substitutes regarding the hard and soft tissue contours of the augmented ridge. Material & Methods Two semi‐saddle bone defects were prepared in each side of the mandible of eight dogs, and one titanium implant was inserted into every defect. The defects were randomly allocated to receive one of the following treatments: bone augmentation by GBR using (1) particulate deproteinized bovine bone mineral ( DBBM ) + a collagen membrane ( CM ), (2) block DBBM + CM , (3) equine bone substitute block + CM , and (4) empty controls. After 4 months, the jaws were scanned by means of cone beam computed tomography ( CBCT ). CBCT analysis was performed in one central and two lateral (mesial and distal) regions of interest ( ROI ) of each site evaluating the horizontal thickness of the augmented hard tissue ( HT hard tisue ) and the total thickness of hard and soft tissue ( HT total ). The Wilcoxon‐Pratt signed rank test was used for statistical analysis. Results In the majority of ROI s, equine and bovine blocks rendered significantly higher values in HT hard tissue and HT total than controls ( P < 0.05). Generally, equine blocks reached the highest values in HT hard tissue and HT total followed by DBBM blocks and particulate DBBM . The differences in HT hard tissue and HT total between GBR groups were not statistically significant ( P > 0.05). In the central ROI , HT hard tissue at the level of the implant shoulder measured 1.7 ± 1.4 mm for equine blocks, 1.7 ± 1.0 mm for DBBM blocks, 0.9 ± 1.2 mm for particulate DBBM , and 0 ± 0 mm for controls. The corresponding values in the lateral ROI reached 1.9 ± 1.1 mm for equine blocks, 1.2 ± 0.8 mm for DBBM blocks, 1.0 ± 0.9 mm for particulate DBBM , and 0 ± 0 mm for controls. Conclusions GBR with bone substitute blocks lead to higher ridge dimensions than empty controls. The equine block with CM rendered the most favorable outcomes in hard and soft tissue contours followed by DBBM block and DBBM granulate with CM .