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Impact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
Author(s) -
Lambert France,
Bacevic Miljana,
Layrolle Pierre,
Schüpbach Peter,
Drion Pierre,
Rompen Eric
Publication year - 2017
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12986
Subject(s) - hydroxyapatites , sinus lift , biomaterial , biomedical engineering , materials science , in vivo , dentistry , chemistry , maxillary sinus , metallurgy , medicine , biology , microbiology and biotechnology , calcium
Aims The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone‐to‐material contact (osteoconductivity), of three hydroxyapatite‐based biomaterials ( HA ) of different origins (natural or synthetic) or manufacturing process in a sinus lift model in rabbits. The secondary objective was to correlate the findings with the physical and topographical characteristics of the biomaterials. Materials and Methods Two bovine HA manufactured with different processes (bovine hydroxyapatites [BHA] and cuttlebone hydroxyapatite [CBHA]) and a synthetic hydroxyapatite ( SHA ) sintered at high temperature were characterised with scanning electronic microscopy ( SEM ) and the measurement of specific surface area ( BET ). The materials were implanted in a sinus lift model in rabbits; histological and histomorphometric evaluation using non‐decalcified sections was performed at 1, 5 and 12 weeks after implantation. Results The studied biomaterials displayed a different surface topography. The two natural HA displayed significantly higher bone quantities ( P = 0.0017; BHA vs. SHA , P = 0.0018 and CBHA vs. SHA , P = 0.033) at 5 and 12 weeks compared to the synthetic one ( SHA ). Moreover, the osteoconductivity (bone‐to‐material contact) was significantly higher in the BHA group compared to the two other groups ( P = 0.014; BHA vs. SHA , P = 0.023 and BHA vs. CBHA , P = 0.033). Conclusion HA ‐based biomaterials from diverse origins and manufacturing processes displayed different topographical characteristics. This may have influenced different regenerated bone architecture observed; more bone was found with natural HA compared to the synthetic one, and significantly higher bone‐to‐material contacts were found with BHA .