Premium
Sequential morphometric evaluation at UnicCa ® and SLA ctive ® implant surfaces. An experimental study in the dog
Author(s) -
Favero Vittorio,
Lang Niklaus P.,
Favero Riccardo,
Carneiro Martins Neto Evandro,
Salata Luiz A.,
Botticelli Daniele
Publication year - 2017
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12906
Subject(s) - implant , osseointegration , soft tissue , bone marrow , bone healing , dentistry , matrix (chemical analysis) , bone formation , mandible (arthropod mouthpart) , chemistry , biomedical engineering , medicine , anatomy , surgery , pathology , biology , botany , genus , chromatography
Aim To study sequential osseointegration around implants with nano‐technologically modified surfaces at different periods of healing. Materials and methods After 3 months, two different implant systems with different nano‐technologically modified surfaces were randomly installed in the edentulous molar regions of the mandible of 12 dogs. One surface was acid‐etched surface, and subsequently modified with calcium ions (UnicCa ® ), while the other was a hydrophilic sandblasted with large grit and acid‐etched ( SLA ctive ® ) surface. The implants were fully submerged, and biopsies were obtained representing the healing after 1, 2, 4 and 8 weeks ( n = 6 per period). A morphometric evaluation of densities of new soft tissues (provisional matrix and immature bone marrow), new and old bone, mature bone marrow, vessels and other tissues (bone debris/particles and clot) was performed in the spongiosa compartment of the sites of implantation. Results After 1 week of healing, the soft tissues, mainly composed of provisional matrix, were present at 41.5 ± 23.9% and 30.1 ± 20.0% at the UnicCa ® and SLA ctive surfaces, respectively. These percentages were >40% at both surfaces after 2 weeks of healing, presenting greater amount of immature bone marrow. Subsequently, these percentages decreased up to disappear after 8 weeks of healing. New bone increased progressively between 1 and 8 weeks of healing from 8.2 ± 3.0% to 77.1 ± 6.4% and from 6.8 ± 2.8% to 67.9 ± 6.8% at the UnicCa ® and SLA ctive ® , respectively. Old bone decreased progressively over time. Conclusions The patterns of healing at highly hydrophilic surfaces occurred through the early formation of a provisional matrix followed by the formation of new bone and marrow at various stages of maturation. The healing was similar to those described in different animal models, anatomical sites and surgical procedures.