Premium
Th17‐related cytokines in mucositis: is there any difference between peri‐implantitis and periodontitis patients?
Author(s) -
Teixeira Mayla Kezy Silva,
LiraJunior Ronaldo,
Telles Daniel Moraes,
Lourenço Eduardo José Veras,
Figueredo Carlos Marcelo
Publication year - 2017
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12886
Subject(s) - mucositis , peri implantitis , periodontitis , medicine , dental alveolus , dentistry , bleeding on probing , significant difference , clinical attachment loss , dental implant , gastroenterology , implant , surgery , toxicity
Objective This study aimed to compare Th17‐related cytokines named IL ‐1β, IL ‐4, IL ‐6, IL ‐10, IL ‐17A, IL ‐17F, IL ‐21, IL ‐22, IL ‐23, IL ‐25, IL ‐31, IL ‐33, IFN ‐γ, sCD 40L and TNF ‐α in peri‐implant fluid ( PIF ) from mucositis sites in patients having either peri‐implantitis, periodontitis or without interproximal alveolar bone loss. Material and methods Thirty‐three patients diagnosed with peri‐implant mucositis were divided into three groups: individuals with peri‐implant mucositis but without any signs of interproximal alveolar bone loss (group 1, n = 10), individuals with peri‐implantitis (group 2, n = 14) and individuals with periodontitis (group 3, n = 9). Probing depth ( PD ), clinical attachment level ( CAL ), visible plaque index and bleeding on probing were measured. PIF was collected from mucositis sites in patients from the three groups and from peri‐implantitis (group 2) and periodontitis sites (group 3). Cytokines were measured by a bead‐based multiplex assay. Results Probing depth was significantly lower in group 1 when compared to both groups 2 and 3 ( P < 0.001 and P = 0.01, respectively). There was no significant difference in cytokine levels in mucositis sites among the three groups. In group 2, IL‐21 level was significantly higher in mucositis compared to peri‐implantitis sites ( P = 0.04). Conclusion The expression of Th17‐related cytokines in PIF from mucositis sites seems to be similar regardless the presence or not of alveolar bone loss around implants or teeth.