Premium
The influence of locally applied granulocyte‐colony stimulating factor on osteoporotic bone
Author(s) -
Liu Xi Ling,
Rao Nian Jing,
Huo Lei,
Hu Xiang,
Lu Weijia William,
Zheng Li Wu
Publication year - 2017
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12839
Subject(s) - medicine , granulocyte colony stimulating factor , femur , bone formation , population , surgery , dentistry , urology , chemotherapy , environmental health
Objectives The compromised capacity of bone healing in osteoporotic population renders a serious concern of patients and clinicians. This study aimed to investigate the influence of G‐ CSF on bone reconstruction using an osteoporotic animal model. Materials and methods Sixty skeletal mature female Spraque–Dawley rats underwent bilateral ovariectomy (OVX) and were assigned into three groups ( n = 20). Three months after OVX, defects of 5 mm in cranial and 2 mm in femur were surgically created on all the animals. The defects were left unfilled, filled with gelatin sponge (GS), or filled with granulocyte‐colony stimulating factor (G‐ CSF ) infused GS. Specimens were retrieved for histomorphometric and micro‐ CT analyses at weeks 1, 4, 8, and 12 after surgery. Results At early stage of week 1 to week 8, the histomorphometric and micro‐ CT analysis demonstrated more advanced bone formation in femur in the control group; by week 12, all groups achieved cortical closure. In cranial bone, more advanced bone formation was exhibited in G‐ CSF ‐treated group at both early and late stages, although this observation was not statistically significant. Conclusions The results indicated that in osteoporotic bone, G‐ CSF may advance bone healing in cranial bone where spontaneous bone formation was insufficient.