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Guided bone regeneration in osteoporotic conditions following treatment with zoledronic acid
Author(s) -
Mardas Nikos,
Busetti Juliano,
Figueiredo José Antonio Poli,
Mezzomo Luis André,
Scarparo Roberta Kochenborger,
Donos Nikolaos
Publication year - 2017
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12810
Subject(s) - zoledronic acid , osteoporosis , medicine , bone healing , urology , dentistry , surgery
Objectives To evaluate new bone formation in calvarial critical size defects ( CSD ) under dense polytetrafluoroethylene (d‐ PTFE ), microporous membranes for guided bone regeneration ( GBR ) in healthy, osteoporotic and osteoporotic treated with zoledronic acid ( ZA ) rats. Methods Forty‐eight, female, 6‐month old Wistar rats were included in the study. Osteoporosis was induced by ovariectomy ( OVX ) and calcium‐deficient diet in 32 rats. Sixteen OVX rats were treated with a single dose of Zolendronic Acid ( ZA ) ( OZ ), while 16 OVX rats received no treatment (O). The remaining 16 rats were sham‐operated and used as healthy controls (C). At 6 weeks following osteoporosis induction, two 5 mm CSD were created in the parietal bones and one of them was treated with a double d‐ PTFE membrane. The healing periods were 30 and 60 days. New bone formation ( NB ) was assessed by qualitative and quantitative histological analysis. Results After 30 days of healing, NB (mean% (95% CI )) was 78.9% (21), 93.1% (9.3) and 84.2% (26.9) in the membrane treated defects and 18.8% (24.1), 27.1% (7.9) and 31% (38.8) in the untreated defects of group O, OZ and C, respectively. After 60 days of healing, NB was 78.3% (14.4), 95.8% (9) and 90.1% (26.1) in the membrane treated defects and 10.8% (17.4), 51.6% (39.4) and 15.7% (12.1) in the untreated defects of group O, OZ and C, respectively. Hierarchical analysis of variance showed that treatment with ZA ( P = 0.001) and the use of membrane ( P = 0.000) significantly increased new bone formation while presence of osteoporosis may have reduced new bone formation ( P = 0.028). Conclusion d‐ PTFE membranes for GBR promote bone healing in osteoporotic and healthy rats. Treatment with ZA may improve new bone formation in osteoporotic rats.