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Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs
Author(s) -
SalomóColl O.,
MatéSánchez J. E. Val,
RamírezFernandez M. P.,
HernándezAlfaro F.,
GargalloAlbiol J.,
CalvoGuirado J. L.
Publication year - 2018
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12809
Subject(s) - osseointegration , medicine , dentistry , implant , premolar , beagle , surgery , molar
Objective The aim of this study was to evaluate the effects on osseointegration of topical applications of melatonin vs. vitamin D over surfaces of immediate implants. Materials and methods Mandibular premolar distal roots (P 2 , P 3 , P 4 ) were extracted bilaterally from six American Foxhound dogs. Three conical immediate implants were randomly placed bilaterally in each mandible. Three randomized groups were created: melatonin 5% test group ( MI ), vitamin D 10% test group ( DI ), and Control group implants ( CI ). Block sections were obtained after 12 weeks and processed for mineralized ground sectioning. Bone‐to‐implant contact (total BIC ), new bone formation ( NBF ), inter‐thread bone ( ITB ), and histological linear measurements ( HLM ) were assessed. Results At 12 weeks, all implants were clinically stable and histologically osseointegrated. Total BIC values were 49.20 ± 3.26 for the MI group, 49.86 ± 1.89 for DI group and 45.78 ± 4.21 for the CI group ( P < 0.018) with statistically significant difference between the three groups. BIC percentage were 42.44 ± 2.18 for MI , 44.56 ± 1.08 for DI , and 41.95 ± 3.34 for CI groups respectively ( P > 0.05). Inter‐thread bone formation values were MI 17.56 ± 2.01, for DI 19.87 ± 0.92, and CI 14.56 ± 1.24 ( P > 0.05). Statistically significant differences in peri‐implant new bone formation were found between the three groups: MI 28.76 ± 1.98, DI 32.56 ± 1.11 and CI 25.43 ± 4.67, respectively ( P < 0.045). Linear measurements showed that the MI group showed significantly less lingual crestal bone loss ( CBL ) ( MI 0.59 ± 0.71), compared to DI (0.91 ± 1.21) and CI (0.93 ± 1.21) ( P < 0.042), and less lingual peri‐implant mucosa ( PIM ) ( MI 3.11 ± 1.34),( DI 3.25 ± 0.18 compared with CI 3.54 ± 1.81 ( P = 0.429). Linear measurements of buccal CBL showed significantly less buccal bone loss in test DI (0.36 ± 0.12) than CI (1.34 ± 1.23) and MI (1.11 ± 1.38) ( P = 0.078). Conclusions Within the limitations of this animal study, topical applications of 5% Melatonin or 10% vitamin D improved bone formation around implants placed immediately after extraction and helped to reduce CBL after 12 weeks osseointegration.