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RETRACTED: Xenografts Supplemented with Pamindronate placed in postextraction sockets to avoid crestal bone resorption. Experimental study in Fox hound dogs
Author(s) -
LozanoCarrascal Naroa,
DelgadoRuiz Rafael arcesio,
GargalloAlbiol Jordi,
MatéSánchez José Eduardo,
Hernandez Alfaro Federico,
CalvoGuirado José Luis
Publication year - 2016
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12550
Subject(s) - beagle , dentistry , resorption , medicine , molar , histology , connective tissue , bone formation , bone resorption , mandible (arthropod mouthpart) , pathology , biology , botany , genus
Objectives The aim of the study was to compare the effects of porcine xenografts ( MP 3 ® ) with or without pamindronate for the healing of small and large defects of postextraction sockets. Materials and methods Six beagle dogs were used in the study; second premolars and first molars of the mandible were extracted, small defects ( SD ) and large defects ( LD ) were identified. Each defect was measured and randomly filled as follows: SC (small control defects filled with MP 3 ® alone), ST (small test defects filled with MP 3 ® modified with pamindronate), LC (large control defects filled with MP 3 ® alone), LT (large test defects filled with MP 3 ® modified with pamindronate). After 4 and 8 weeks, the animals were euthanized and the percentages of new bone formation ( NB ), residual graft ( RG ) and connective tissue ( CT ) were analysed by histology and histomorphometry of undecalcified samples. Results After 4 weeks, NB formation was higher for ST compared to all groups and for LT compared to LC ( P < 0.05); RG was significantly higher in both control groups compared to tests ( P < 0.05); and CT was higher in large defects ( LC and LT ) compared to small defects. After 8 weeks, NB formation was higher for test groups ( ST and LT ) compared to controls ( P < 0.05); RG was significantly higher in both control groups compared to tests ( P < 0.05); and CT was higher in large defects ( LC and LT ) compared to small defects ( P < 0.05). Conclusions Within the limitations of this experimental study, the findings suggest that porcine xenografts modified with pamindronate favours the new bone formation and increased the porcine xenograft substitution/replacement after 4 and 8 weeks of healing.