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Novel 3 D polycaprolactone scaffold for ridge preservation – a pilot randomised controlled clinical trial
Author(s) -
Goh Bee Tin,
Teh Luan Yook,
Tan Danny Ben Poon,
Zhang Zhiyong,
Teoh Swee Hin
Publication year - 2015
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12486
Subject(s) - resorption , alveolar ridge , dentistry , medicine , scaffold , polycaprolactone , extraction (chemistry) , ridge , implant , bone resorption , biomedical engineering , surgery , materials science , chemistry , biology , pathology , paleontology , chromatography , composite material , polymer
Objectives This pilot randomised controlled clinical trial aimed to evaluate the feasibility and effectiveness of using a polycaprolactone ( PCL ) scaffold in fresh extraction sockets for ridge preservation. The hypothesis was that the insertion of a 3D bioresorbable PCL scaffold in fresh extraction sockets allowed for normal bone healing and better maintenance of ridge dimensions after 6 months as compared to extraction sockets without the scaffold. Material and methods Thirteen patients were randomised to either the test group ( N = 6) where a PCL scaffold was inserted in the tooth socket after extraction or the control group ( N = 7) where no space filler was used. Alveolar ridge height and width measurements were made at baseline and 6 months post‐extraction, for the evaluation of bone resorption. At 6 months, a core of bone was trephined out from the healed ridge for microcomputed tomographic (micro CT ) and histological analyses, immediately before Stage I dental implant surgery. Stage II dental implant surgery was performed 4–6 months later. Results There was less vertical ridge resorption in the test group compared to the control group, and the difference was statistically significant in the mesio‐buccal aspect ( P = 0.008). Micro CT and histological observations showed mainly mineralised bone formation in both groups, except for one specimen in the test group. Conclusions The insertion of a 3D bioresorbable PCL scaffold in fresh extraction sockets allowed for normal bone healing, and there was better maintenance of ridge height after 6 months as compared to extraction sockets without the scaffold.