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Zirconia with laser‐modified microgrooved surface vs. titanium implants covered with melatonin stimulates bone formation. Experimental study in tibia rabbits
Author(s) -
CalvoGuirado José Luis,
Aguilar Salvatierra Antonio,
GargalloAlbiol Jordi,
DelgadoRuiz Rafael Arcesio,
Maté Sanchez Jose Eduardo,
SatorresNieto Marta
Publication year - 2015
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12472
Subject(s) - melatonin , cubic zirconia , titanium , implant , tibia , dentistry , connective tissue , medicine , materials science , surgery , pathology , metallurgy , ceramic
Abstract Objectives The aim of the study was to evaluate if zirconia implants with micro‐grooved surfaces supplemented with melatonin enhance the bone‐to‐implant contact ( BIC ) vs. titanium implants with the same coating. Materials and methods Eighty implants divided in four groups were inserted in the tibia of 20 New Zealand rabbits as follows: (group A) 20 titanium implants; (group B) 20 micro‐grooved zirconia implants; (group C) 20 titanium implants supplemented with melatonin and (group D) 20 micro‐grooved zirconia implants supplemented with melatonin. Histometric and SEM evaluation of BIC were evaluated after 1 and 4 weeks. Results At 1 week, group C (29.7 ± 2.4%) and group D (28.9 ± 1.3%) implants showed higher BIC % compared with group A and B ( P < 0.05). After 4 weeks, group D showed higher BIC compared with all the groups (47.5 ± 2.2%) ( P < 0.05). Also Connective tissue was higher in groups B (78.9 ± 2.1%) and D (88.7 ± 1.2%) related to titanium and zirconia melatonin untreated at 4 weeks ( P < 0.05). Conclusions Within the limitations of this pilot study in rabbits, we can conclude that the local application of melatonin increases the BIC values in titanium and in zirconia implants at 1 week.