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Increase of homogenous new bone formation using osteoinductive factor rh GDF ‐5 during sinus floor augmentation in Goettingen Minipigs
Author(s) -
Brockmeyer Phillipp,
Lange Katharina,
Hahn Wolfram,
Schliephake Henning,
Matthias Gruber Rudolf
Publication year - 2015
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12457
Subject(s) - bone formation , homogeneous , sinus (botany) , growth factor , dentistry , bone growth , chemistry , medicine , endocrinology , biology , receptor , mathematics , botany , combinatorics , genus
Objectives The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor‐5 (rh GDF ‐5) induces an increased and homogenous distribution of new bone formation across the entire volume of sinus floor augmentation in 12 Goettingen Minipigs. Material and Methods In a randomized split‐mouth design, one maxillary sinus was augmented with the bone substitute β‐ TCP , whereas a combination of β‐ TCP and the osteoinductive growth factor rh GDF ‐5 was used on the contralateral side. To evaluate the influence of dose and time on the effectiveness of the factor, two different concentrations of rh GDF ‐5 (400 μg and 800 μg) and healing periods (4 and 12 weeks) were each analysed. Results After 4 weeks, a homogenous gradient of bone formation could be observed for all dosage groups, with decreasing bone density from the local bone towards the sinus membrane. Both test groups, however, achieved a higher total level of bone formation compared with the control group, which was only significant in the low‐dose group ( P = 0.0184). After 12 weeks, the influence of the growth factor significantly depends on the region ( P = 0.023). In the low‐dose group, the new bone formation did not differ significantly within the examined regions of the graft ( P = 0.1118), suggesting a homogeneous bone formation over the entire augmentation. The gradient of the high‐dose group was similar to the control group with a decrease of local bone development. Conclusions rh GDF ‐5 delivered on a β‐ TCP scaffold material leads to an increase in homogeneous new bone formation across the entire volume of the sinus floor augmentation.