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Internal bacterial colonization of implants: association with peri‐implant bone loss
Author(s) -
JervøeStorm PiaMerete,
Jepsen Søren,
Jöhren Peter,
MericskeStern Regina,
Enkling Norbert
Publication year - 2015
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12421
Subject(s) - tannerella forsythia , treponema denticola , prevotella intermedia , fusobacterium nucleatum , implant , aggregatibacter actinomycetemcomitans , peri implantitis , dentistry , bleeding on probing , medicine , porphyromonas gingivalis , clinical attachment loss , periodontitis , bone remodeling , surgery , pathology , honeysuckle , alternative medicine , traditional chinese medicine
Objectives The aim of the present longitudinal study was to investigate bacterial colonization of the internal implant cavity and to evaluate a possible association with peri‐implant bone loss. Methods A total of 264 paper point samples were harvested from the intra‐implant cavity of 66 implants in 26 patients immediately following implant insertion and after 3, 4, and 12 months. Samples were evaluated for Aggregatibacter actinomycetemcomitans , Fusobacterium nucleatum , Porphyromonas gingivalis , Prevotella intermedia , Treponema denticola , and Tannerella forsythia as well as total bacterial counts by real‐time PCR . Bone loss was evaluated on standardized radiographs up to 25 months after implant insertion. For the statistical analysis of the data, mixed effects models were fitted. Results There was an increase in the frequency of detection as well as in the mean counts of the selected bacteria over time. The evaluation of the target bacteria revealed a significant association of Pr. intermedia at 4 and 12 months with peri‐implant bone loss at 25 months (4 months: P = 0.009; 12 months: P = 0.021). Conclusions The present study could demonstrate a progressive colonization by periodontopathogenic bacteria in the internal cavities of two‐piece implants. The results suggest that internal colonization with Pr. intermedia was associated with peri‐implant bone loss.