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RETRACTED: Biphasic β‐TCP mixed with silicon increases bone formation in critical site defects in rabbit calvaria
Author(s) -
CalvoGuirado José Luis,
Garces Miguel,
DelgadoRuiz Rafael Arcesio,
Ramirez Fernandez Maria P.,
FerresAmat Eduard,
Romanos Georgios E.
Publication year - 2015
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12413
Subject(s) - calvaria , resorption , rabbit (cipher) , silicon , materials science , bone formation , parietal bone , biomedical engineering , anatomy , medicine , chemistry , pathology , skull , mathematics , metallurgy , in vitro , biochemistry , statistics
Objective The aim of this study was to assess the bone regeneration of critical size defects in rabbit calvarias filled with β‐ TCP doped with silicon. Materials and methods Twenty‐one New Zealand rabbits were used in this study. Two critical size defects were created in the parietal bones. Three experimental groups were evaluated: Test A ( HA /β‐ TCP granules alone), Test B ( HA /β‐ TCP granules plus 3% silicon), Control (empty defect). The animals were sacrificed at 8 and 12 weeks. Evaluation was performed by μ CT analysis and histomorphometry. Results μ CT evaluation showed higher volume reduction in Test A group compared with Test B ( P < 0.05). The Test B group showed the highest values for cortical closure and bone formation around the particles, followed by Test A and controls ( P < 0.05). Conclusions Within the limitations of this animal study, it can be concluded that HA /β‐ TCP plus 3% silicon increases bone formation in critical size defects in rabbit calvarias, and the incorporation of 3% silicon reduces the resorption rate of the HA /β‐ TCP granules.