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Bone tissue modelling and remodelling following guided bone regeneration in combination with biphasic calcium phosphate materials presenting different microporosity
Author(s) -
Dahlin Christer,
Obrecht Marcel,
Dard Michel,
Donos Nikos
Publication year - 2015
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12361
Subject(s) - mandible (arthropod mouthpart) , dentistry , histology , calcium , molar , regeneration (biology) , chemistry , bone healing , biomedical engineering , materials science , anatomy , medicine , pathology , biology , botany , organic chemistry , genus , microbiology and biotechnology
Objectives The aim of this study was to investigate bone regeneration following application of a novel biphasic calcium phosphate ( BCP I ) composed of microstructured granules of 90% β‐tricalcium phosphate (β‐ TCP )/10% hydroxyapatite ( HA ) compared to BCP non‐microstructured biphasic calcium phosphate with a composite of 60% hydroxyapatite/40% β‐ TCP ( BCP II ) and a deproteinized bovine bone mineral ( DBBM ) at surgically created defects in the mandible of minipigs in a combined approach with guided bone regeneration ( GBR ). Material and methods Sixteen minipigs were used for the study. Lower premolars P 2, P 3, P 4 and first molar M 1 were extracted. Following 3 months of healing, two defects with a width and depth of 7 mm were created bilaterally in the mandible. The different grafting materials were randomly placed in the created defects and covered by means of a collagen membrane. After 3 and 8 weeks, biopsies were sampled. All specimens were evaluated with descriptive histology and histomorphometric evaluations complemented by micro‐ CT scan analysis. Results All three biomaterials presented with higher bone volume at 8 weeks compared to 3 weeks ( P < 0.0442). BCP I and DBBM demonstrated a significant higher amount of bone formation compared to BCP II at 8 weeks ( P < 0.0328). BCP I also demonstrated a significant higher percentage of remaining graft volume compared to the other test groups both at 3 and 8 weeks ( P < 0.0001 to P < 0.0003). Congruently, defects containing BCP I showed a significant higher amount of mineralized tissue compared to the other groups. Conclusions All the three test materials performed well with regard to bone formation at 8 weeks. BCP I showed significant higher amounts of newly formed bone despite a higher remaining graft volume compared to the other groups. With regard to the regenerative outcome, all the three materials can be recommended for clinical use.