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Mandibular bone loss in ewe induced by hypothalamic–pituitary disconnection
Author(s) -
Oheim Ralf,
Beil F. Timo,
Krause Matthias,
Bindl Ronny,
Ignatius Anita,
Pogoda Pia
Publication year - 2014
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12259
Subject(s) - cortical bone , context (archaeology) , bone remodeling , quantitative computed tomography , medicine , disconnection , dental alveolus , bone formation , dentistry , anatomy , bone density , biology , osteoporosis , paleontology , political science , law
Purpose It is supposed that the demographic change will lead to an increase in patients with impaired alveolar bone conditions. Large animal models are of particular interest in this context as they are suitable for developing and testing new dental implants. Recently, we demonstrated that surgical hypothalamo–pituitary disconnection ( HPD ) causes a pronounced low‐turnover situation leading to cortical and trabecular bone loss in sheep. In this study, we aimed to investigate the influence of the HPD procedure on the alveolar bone. Methods Ten adult Merino ewes were randomly assigned to two groups: Control and HPD . After 6 months, we analysed the cortical and trabecular bone of all mandibles by histomorphometry and high‐resolution peripheral quantitative computed tomography (HR‐ pQCT ). Results HPD ewes showed a significant decrease in cortical thickness by ~20%, a significant increase in cortical porosity by ~20% and a significant decrease in bone volume by ~30% in comparison with Control ewes. Conclusion Our results underline the importance of central regulatory mechanisms of bone turnover. However, further studies are needed to understand these central regulatory elements of bone turnover in detail and to judge the value of the HPD sheep for dental research.