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Impact of autogenous concentrated bone marrow aspirate on bone regeneration after sinus floor augmentation with a bovine bone substitute – a split‐mouth pilot study
Author(s) -
Wildburger Angelika,
Payer Michael,
Jakse Norbert,
Strunk Dirk,
EtchardLiechtenstein Nathalie,
Sauerbier Sebastian
Publication year - 2014
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12228
Subject(s) - sinus (botany) , dentistry , biomaterial , medicine , bone marrow , mesenchymal stem cell , surgery , pathology , biomedical engineering , biology , botany , genus
Purpose Mesenchymal stem cells ( MSC ) with biomaterials have osteoinductive potential. The aim of this study was to evaluate early bone formation in xenogenic sinus grafts in a direct comparison with and without MSC s after 3 and 6 months. Literature on bone formation in pure xenogenic graft materials after 3 months in a human model is still lacking. Materials and methods In a split‐mouth design, seven patients with a bilateral highly atrophic posterior maxilla were included. The test side was grafted with MSC s from concentrated bone marrow aspirate admixed to the bone graft material. On the control side, pure bovine bone material was applied. Biopsies were taken navigated after 3 and 6 months. Results After 3 months, new bone formation in the control group was 11.8% (SD 6.2%) and in the test group 7.4% (SD 4.1%). After 6 months, the control group showed 13.9% (SD 8.5%) of new bone and the test group 13.5% NB (SD 5.4%). The fraction of bovine bone material after 3 months was 42.6% (SD 3.5%) in the test group and 34.9% (SD 11.8%) in the control group. After 6 months, the biomaterial content was comparable at both sides (test 36.2%, SD 7.8%; control 39.5%, SD 9.3%). Conclusions There was no significant difference in new bone formation between the test and control group with n = 7. The results may be dominated by the high mineral content of the biomaterial but could nevertheless be valuable for meta‐analysis in the future.