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Effect of systemic antibiotics on clinical and patient‐reported outcomes of implant therapy – a multicenter randomized controlled clinical trial
Author(s) -
Tan Wah Ching,
Ong Marianne,
Han Jie,
Mattheos Nikos,
Pjetursson Bjarni E.,
Tsai Alex YiMin,
Sanz Ignacio,
Wong May C.M.,
Lang Niklaus P.
Publication year - 2014
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12098
Subject(s) - medicine , implant , surgery , placebo , visual analogue scale , randomized controlled trial , anesthesia , clinical trial , alternative medicine , pathology
Objectives To determine the effect of various systemic antibiotic prophylaxis regimes on patient‐reported outcomes and postsurgical complications in patients undergoing conventional implant installation. Material and methods Three hundred and twenty‐nine healthy adults in need of conventional implant installation were randomly assigned to one of four groups: (i) preoperatively 2 g of amoxycillin 1 h before surgery (positive control, PC ), (ii) postoperatively 2 g of amoxycillin immediately following surgery (test 1, T1), (iii) preoperatively 2 g of amoxycillin 1 h before and 500 mg thrice daily on days 2 and 3 after surgery (test 2, T2), (iv) preoperatively 2 g of placebo 1 h before surgery (negative control, NC ). Subjects were examined clinically by blinded examiners over 8 weeks after implant installation. In addition, Visual Analogue Scales ( VAS ) for pain, swelling, bruising and bleeding were obtained over 14 days. ANOVA was performed for the VAS . Chi‐square tests were applied for postsurgical complications. Results All VAS scores were low for all groups and decreased over time ( P < 0.001). There were no significant differences for the VAS scores between the various groups at any time point ( P > 0.05). There was only a significant difference in flap closure at week 4, where NC had 5% of the subjects not achieving complete wound closure compared to 0% for the three other groups ( P = 0.01), with no other significant differences for any postsurgical complications ( P > 0.05). Conclusion For standard single implant placement, prophylactic systemic antibiotics either before or after, or before and after the surgical procedure do not improve patient‐reported outcomes or prevalence of postsurgical complications.