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Bone formation around zirconia implants combined with rh BMP ‐2 gel in the canine mandible
Author(s) -
Lee ByungChul,
Yeo InSung,
Kim DaeJoon,
Lee JaiBong,
Kim SungHun,
Han JungSuk
Publication year - 2013
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/clr.12004
Subject(s) - osseointegration , cubic zirconia , dentistry , implant , bone morphogenetic protein 2 , titanium , mandible (arthropod mouthpart) , beagle , bone formation , materials science , medicine , chemistry , surgery , in vitro , biology , ceramic , biochemistry , botany , composite material , metallurgy , genus
Objective The aim of this study was to estimate the effects of zirconia implants and recombinant human bone morphogenetic protein‐2 (rh BMP ‐2) gel on the acceleration of local bone formation and osseointegration in the canine mandible. Materials and Methods Four groups of 48 implants with identical geometry were installed in the mandibles of beagle dogs: alumina‐blasted zirconia implants applied with rh BMP ‐2, alumina‐blasted zirconia implants applied with demineralized bone matrix ( DBM ), alumina‐blasted zirconia implants, and resorbable blast media‐treated titanium ( T i) implants. For the first two groups, zirconia implants were inserted after the surgical sites were filled with rh BMP ‐2 or DBM gel. For the other two groups, zirconia or Ti implants were installed with no adjunctive treatment. Fluorescent bone markers were administered to monitor bone remodeling at weeks 2, 4, and 5 postimplantation. After healing periods of 3 weeks and 6 weeks, the animals were sacrificed, and fluorescent microscopy, histology, and histomorphometric analyses were performed. Results Fluorescent microscopy showed that bone formation around the zirconia implants installed with rh BMP ‐2 gel was the most prominent at 2 weeks postimplantation, while the Ti implants acquired bone apposition mainly at week 5. No significant differences were found in bone area among the groups ( P > 0.05). The zirconia implants showed similar bone‐to‐implant contact to the T i implants. There were no significant differences in bone‐to‐implant contact between the zirconia implants with rh BMP ‐2 gel and those with DBM ( P > 0.05). Conclusions The zirconia implants with alumina‐blasted surfaces may achieve osseointegration in much the same manner as the well‐established T i implants. The area influenced by rh BMP ‐2 gel, including the alveolar crest, may cause active remodeling and early bone formation.