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Histological assessment of mandibular bone tissue after guided bone regeneration with customized computer‐aided design/computer‐assisted manufacture titanium mesh in humans: A cohort study
Author(s) -
Dellavia Claudia,
Canciani Elena,
Pellegrini Gaia,
Tommasato Grazia,
Graziano Daniele,
Chiapasco Matteo
Publication year - 2021
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.13025
Subject(s) - osseointegration , dental alveolus , medicine , dentistry , osteoid , regeneration (biology) , titanium , biomedical engineering , materials science , implant , pathology , surgery , biology , metallurgy , microbiology and biotechnology
Background Innovative customized computer‐aided design/computer‐assisted manufacture (CAD‐CAM) titanium meshes have been proposed for guided alveolar bone regeneration. Histological confirmation on the quality of the regenerated bone is needed. Purpose of the study is to assess the integration capabilities of these innovative meshes and to evaluate the histological features of the regenerated alveolar bone. Materials and methods Twenty partially edentulous patients, with severe posterior mandibular atrophy, underwent a guided bone regeneration technique by means of customized CAD‐CAM titanium mesh in association with a mixture of autologous bone in chips and deproteinized bovine bone (1:1). At 9 months of healing, titanium meshes and bone samples were collected and histomorphometrically analyzed. Results In all patients, implants were placed according to the original plan. At histologic analysis, mesh appeared well osseointegrated, except that in sites where membrane exposure occurred. In all sites, newly formed tissue resulted highly mineralized, well‐organized, and formed by 35.88% of new lamellar bone, 16.42% of woven bone, 10.88% of osteoid matrix, 14.10% of grafted remnants, and 22.72% of medullary spaces. Blood vessels were the 4% of the tissue. Conclusions Data from this study support the use of customized CAD/CAM titanium mesh for regeneration of vital, well‐structured, and vascularized alveolar bone.